A Holistic Approach to Insulin Resistance: Exploring the Link Between Fat Accumulation, Glucose Levels, and Personalized Metformin Dosage
Abstract: This paper explores the physiological and behavioral patterns observed over a 25-year period in an individual managing insulin resistance and associated weight gain. It investigates the disconnect between normal postprandial glucose readings and persistent fat accumulation, highlighting the role of underlying insulin resistance. Observations of metformin extended-release (XR) dosing strategies are discussed, particularly how subjective and objective metrics inform optimal dosage. The study also underscores the need for individualized treatment approaches that prioritize insulin sensitivity over glucose control alone. 1. Introduction Insulin resistance (IR) is a metabolic condition wherein cells in muscles, fat, and liver become less responsive to insulin, resulting in impaired glucose uptake and increased fat storage. While hyperglycemia is commonly used to diagnose metabolic dysfunction, many individuals with IR maintain normal blood glucose readings while still ex...